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Biomacromolecules. 2012 Oct 8;13(10):3031-8. doi: 10.1021/bm300520u. Epub 2012 Sep 11.

Localized delivery of dexamethasone from electrospun fibers reduces the foreign body response.

Author information

1
Department of Chemical Engineering, Massachusetts Institute of Technology , Cambridge, MA, USA.

Abstract

Synthetic scaffolds are crucial to applications in regenerative medicine; however, the foreign body response can impede regeneration and may lead to failure of the implant. Herein we report the development of a tissue engineering scaffold that allows attachment and proliferation of regenerating cells while reducing the foreign body response by localized delivery of an anti-inflammatory agent. Electrospun fibers composed of poly(l-lactic) acid (PLLA) and poly(ε-caprolactone) (PCL) were prepared with and without the steroid anti-inflammatory drug, dexamethasone. Analysis of subcutaneous implants demonstrated that the PLLA fibers encapsulating dexamethasone evoked a less severe inflammatory response than the other fibers examined. They also displayed a controlled release of dexamethasone over a period of time conducive to tissue regeneration and allowed human mesenchymal stem cells to adhere to and proliferate on them in vitro. These observations demonstrate their potential as a building block for tissue engineering scaffolds.

PMID:
22920794
PMCID:
PMC3466020
DOI:
10.1021/bm300520u
[Indexed for MEDLINE]
Free PMC Article

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