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Radiology. 2012 Sep;264(3):619-20. doi: 10.1148/radiol.12121378.

Science to practice: can macrophage infiltration serve as a surrogate marker for stem cell viability?

Author information

1
Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine 720 Rutland Ave, 217 Traylor, Baltimore, MD 21205, USA. jwmbulte@mri.jhu.edu

Abstract

Following in vivo prelabeling of host macrophages with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles, it was shown that their magnetic resonance (MR) imaging–visible migration into knee implants of scaffolded adipose-derived stem cells (ADSCs) undergoing apoptosis can serve as a surrogate marker of stem cell death.

PMID:
22919033
DOI:
10.1148/radiol.12121378
[Indexed for MEDLINE]
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