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Gastroenterol Clin North Am. 2012 Sep;41(3):603-10. doi: 10.1016/j.gtc.2012.06.008. Epub 2012 Jul 6.

Diarrhea caused by circulating agents.

Author information

1
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Abstract

Circulating agents cause intestinal secretion or changes in motility with decreased intestinal transit time, resulting in secretory-type diarrhea. Secretory diarrhea as opposed to osmotic diarrhea is characterized by large-volume, watery stools, often more than 1 L per day; by persistence of diarrhea when patients fast; and by the fact that on analysis of stool-water, measured osmolarity is identical to that calculated from the electrolytes present. Although sodium plays the main role in water and electrolyte absorption, chloride is the major ion involved in secretion.

PMID:
22917166
DOI:
10.1016/j.gtc.2012.06.008
[Indexed for MEDLINE]

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