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J Virol. 2012 Nov;86(21):11931-4. doi: 10.1128/JVI.01349-12. Epub 2012 Aug 22.

Internal catalase protects herpes simplex virus from inactivation by hydrogen peroxide.

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1
Department of Microbiology, Immunology, and Cancer Biology, University of Virginia Health System, Charlottesville, Virginia, USA.

Abstract

Herpes simplex virus 1 (HSV-1) was shown to contain catalase, an enzyme able to detoxify hydrogen peroxide by converting it to water and oxygen. Studies with a catalase inhibitor indicated that virus-associated catalase can have a role in protecting the virus from oxidative inactivation. HSV-1 was found to be more sensitive to killing by hydrogen peroxide in the presence of a catalase inhibitor than in its absence. The results suggest a protective role for catalase during the time HSV-1 spends in the oxidizing environment outside a host cell.

PMID:
22915822
PMCID:
PMC3486305
DOI:
10.1128/JVI.01349-12
[Indexed for MEDLINE]
Free PMC Article
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