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Lupus. 2012 Nov;21(13):1455-8. doi: 10.1177/0961203312458470. Epub 2012 Aug 22.

Familial amyloidotic polineuropathy and systemic lupus.

Author information

1
Department of Nephrology, Centro Hospitalar de Lisboa Central, Hospital de Curry Cabral, Lisbon, Portugal. karinadacostafer@hotmail.com

Abstract

Familial amyloidotic polineuropathy is a genetic disorder, leading to systemic amyloid deposits, manifested as sensory-motor and autonomic neuropathy. In the Portuguese classical form, the disease is evident at a young age, and causes death if no specific treatment is received. Variability in penetrance, age of onset and clinical course has been published; environmental and genetic factors are believed to contribute to this variability. The authors report a case of a 51-year-old white female, with a medical history of acquired angioedema, late-onset familial amyloidotic polineuropathy and systemic lupus erythemathosus. The authors consider that these associated diseases could modulate their expression.

PMID:
22914816
DOI:
10.1177/0961203312458470
[Indexed for MEDLINE]

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