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J Hum Lact. 2012 Nov;28(4):543-6. doi: 10.1177/0890334412453205. Epub 2012 Aug 20.

Differential expression of cancer-related proteins in paired breast milk samples from women with breast cancer.

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  • 1University of Massachusetts at Amherst, Amherst, MA, USA.

Abstract

BACKGROUND:

Breast cancer risk increases during pregnancy and remains elevated for a number of years thereafter. Cancer-associated proteins that are secreted into breast milk may provide a means to detect cancer in the lactating breast or to assess future breast cancer risk.

OBJECTIVE:

To determine whether proteins linked to breast cancer would be differentially expressed in matched (both breasts from each participant) human milk samples collected from women with unilateral breast cancer.

METHODS:

Five cancer-associated proteins (basic fibroblast growth factor [bFGF], YKL-40, neutrophil gelatinase-associated lipocalin, and transforming growth factor β1 and β2) were analyzed in milk provided by 5 lactating women, 4 of whom were known to have cancer in 1 breast (and the opposite breast clinically disease free) at the time of milk collection and 1 who developed breast cancer 2 years after milk collection.

RESULTS:

Expression was significantly higher for TGFβ2 (P = .03) and bFGF (P =.03) in the breasts with cancer.

CONCLUSION:

These proteins may play a role in assessing a woman's risk of pregnancy-associated breast cancer. Because of variable protein concentration among patients and the limited sample size, the results are considered preliminary.

[PubMed - indexed for MEDLINE]
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