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Clin Vaccine Immunol. 2012 Oct;19(10):1697-9. Epub 2012 Aug 22.

Pilot phase IB clinical trial of an alhydrogel-adsorbed recombinant ricin vaccine.

Author information

1
Cancer Immunobiology Center, University of Texas Southwestern Medical School, Dallas, USA. ellen.vitetta@utsouthwestern.edu

Abstract

There is no FDA-approved vaccine for the potent plant toxin ricin. We have developed a recombinant ricin vaccine, RiVax. Without adjuvant it is safe and immunogenic in mice, rabbits, and humans. Based on our studies in mice, we now report the results of a small clinical trial with Alhydrogel-adsorbed RiVax.

PMID:
22914366
PMCID:
PMC3485895
DOI:
10.1128/CVI.00381-12
[Indexed for MEDLINE]
Free PMC Article
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