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Org Lett. 2012 Sep 7;14(17):4622-5. doi: 10.1021/ol3020732. Epub 2012 Aug 22.

Construction of nitrogen-fused tetrahydroquinolines via a domino reaction.

Author information

1
Institut de Chimie Organique et Analytique, Université d'Orléans, UMR 7311 CNRS, rue de Chartres, F-45067 Orléans Cedex 2, France.

Abstract

An efficient domino approach for the diastereoselective synthesis of polyfunctionalized nitrogen-fused tetrahydroquinoline frameworks under mild conditions has been developed. The scope and limitation of this transformation were investigated by using a range of readily accessible enamides and benzyl azides. This method is also applicable to the formation of 2,3-functionalized enamides.

PMID:
22913435
DOI:
10.1021/ol3020732

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