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Future Microbiol. 2012 Aug;7(8):991-1002. doi: 10.2217/fmb.12.74.

Klebsiella pneumoniae and type 3 fimbriae: nosocomial infection, regulation and biofilm formation.

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Department of Microbiology, University of Iowa College of Medicine, Iowa City, IA 52242, USA.

Erratum in

  • Future Microbiol. 2012 Oct;7(10):1234.


The Gram-negative opportunistic pathogen Klebsiella pneumoniae is responsible for causing a spectrum of nosocomial and community-acquired infections. Globally, K. pneumoniae is a frequently encountered hospital-acquired opportunistic pathogen that typically infects patients with indwelling medical devices. Biofilm formation on these devices is important in the pathogenesis of these bacteria, and in K. pneumoniae, type 3 fimbriae have been identified as appendages mediating the formation of biofilms on biotic and abiotic surfaces. The factors influencing the regulation of type 3 fimbrial gene expression are largely unknown but recent investigations have indicated that gene expression is regulated, at least in part, by the intracellular levels of cyclic di-GMP. In this review, we have highlighted the recent studies that have worked to elucidate the mechanism by which type 3 fimbrial expression is controlled and the studies that have established the importance of type 3 fimbriae for biofilm formation and nosocomial infection by K. pneumoniae.

[Indexed for MEDLINE]

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