Format

Send to

Choose Destination
See comment in PubMed Commons below
J Matern Fetal Neonatal Med. 2013 Jan;26(2):143-5. doi: 10.3109/14767058.2012.722731. Epub 2012 Sep 12.

The fetal fraction of cell-free DNA in maternal plasma is not affected by a priori risk of fetal trisomy.

Author information

1
Riverside Perinatal Diagnostic Center, Riverside, CA, USA.

Abstract

OBJECTIVE:

To determine the relationship between a priori risk for fetal trisomy and the fraction of fetal cell-free DNA (cfDNA) in maternal blood.

METHODS:

A comparative analysis on fetal cfDNA amounts was performed in subjects stratified into a priori risk groups based on maternal age, prenatal screening results, or nuchal translucency measurement.

RESULTS:

Across the highest and lowest deciles within each group, there were no significant differences in the fetal cfDNA fraction.

CONCLUSIONS:

These data support the concept that non-invasive prenatal test performance as determined by fetal cfDNA fraction is not predicted to be different based on patient risk classification.

PMID:
22913322
PMCID:
PMC3545542
DOI:
10.3109/14767058.2012.722731
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis Icon for PubMed Central
    Loading ...
    Support Center