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Development. 2012 Sep;139(18):3326-31. doi: 10.1242/dev.079418.

Slit2 and Robo3 modulate the migration of GnRH-secreting neurons.

Author information

1
Department of Cell and Developmental Biology, University College London, London WC1E 6BT UK. a.cariboni@ucl.ac.uk

Abstract

Gonadotropin-releasing hormone (GnRH) neurons are born in the nasal placode and migrate along olfactory and vomeronasal axons to reach the forebrain and settle in the hypothalamus, where they control reproduction. The molecular cues that guide their migration have not been fully identified, but are thought to control either cell movement directly or the patterning of their axonal substrates. Using genetically altered mouse models we show that the migration of GnRH neurons is directly modulated by Slit2 and Robo3, members of the axon guidance Slit ligand and Robo receptor families. Mice lacking Slit2 or Robo3 have a reduced number of GnRH neurons in the forebrain, but a normal complement of their supporting axons, pointing to a direct role for these molecules in GnRH neuron migration.

PMID:
22912413
PMCID:
PMC3424043
DOI:
10.1242/dev.079418
[Indexed for MEDLINE]
Free PMC Article
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