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Development. 2012 Sep;139(18):3263-76. doi: 10.1242/dev.078626.

Principles and roles of mRNA localization in animal development.

Author information

1
Institute of Biology Valrose, University of Nice-Sophia Antipolis/UMR7277 CNRS/UMR1091 INSERM, Parc Valrose, 06108 Nice Cedex 2, France.

Abstract

Intracellular targeting of mRNAs has long been recognized as a means to produce proteins locally, but has only recently emerged as a prevalent mechanism used by a wide variety of polarized cell types. Localization of mRNA molecules within the cytoplasm provides a basis for cell polarization, thus underlying developmental processes such as asymmetric cell division, cell migration, neuronal maturation and embryonic patterning. In this review, we describe and discuss recent advances in our understanding of both the regulation and functions of RNA localization during animal development.

PMID:
22912410
PMCID:
PMC3424039
DOI:
10.1242/dev.078626
[Indexed for MEDLINE]
Free PMC Article

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