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Autophagy. 2012 Oct;8(10):1526-8. doi: 10.4161/auto.21155. Epub 2012 Aug 22.

ER stress and autophagy contribute to CsA-induced death of malignant glioma cells.

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1
Laboratory of Transcription Regulation, Department of Cell Biology, Nencki Institute of Experimental Biology, Warsaw, Poland. jcjech@nencki.gov.pl

Abstract

Cyclosporine A (CsA), which revolutionized transplantology due to its ability to block the activation of lymphocytes and other immune system cells, triggers autophagy in malignant glioma cell lines via stimulation of endoplasmic reticulum (ER) stress. We also found that autophagy serves as a protective mechanism against CsA toxicity.

PMID:
22910018
DOI:
10.4161/auto.21155
[Indexed for MEDLINE]
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