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Antimicrob Agents Chemother. 2012 Nov;56(11):6019-20. doi: 10.1128/AAC.00974-12. Epub 2012 Aug 20.

In vivo selection of rifamycin-resistant Clostridium difficile during rifaximin therapy.

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  • 1TechLab, Inc., Blacksburg, Virginia, USA. rjcarman@techlab.com

Abstract

We report the selection of Clostridium difficile resistant to the rifamycin class of antibiotics in a patient within 32 h of receiving rifaximin for the treatment of recurrent C. difficile diarrhea. Resistance was associated with single nucleotide substitutions within rpoB.

PMID:
22908175
PMCID:
PMC3486587
DOI:
10.1128/AAC.00974-12
[PubMed - indexed for MEDLINE]
Free PMC Article
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