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J Trop Pediatr. 2013 Feb;59(1):17-22. doi: 10.1093/tropej/fms036. Epub 2012 Aug 20.

Effect of therapeutic hypothermia on oxidative stress and outcome in term neonates with perinatal asphyxia: a randomized controlled trial.

Author information

1
Department of Pediatrics Neonatology Division, Jawaharlal Institute of Postgraduate Medical Education and Research JIPMER, Puducherry 605 006, India.

Abstract

OBJECTIVES:

To evaluate in term babies with perinatal asphyxia, the effect of therapeutic hypothermia (TH) on oxidative stress and neurological outcome at discharge.

METHODS:

Babies who satisfied inclusion criteria were randomized to TH, with cooling gel packs to a target temperature of 33-34°C for 72 h or normothermia. Blood sample was collected before and after TH for oxidative stress assessment: total antioxidant status (TAS) and malondialdehyde (MDA).

RESULTS:

Of 116 babies randomized, there was no statistically significant difference in the baseline TAS and MDA. After 72 h of TH, TAS was significantly higher (p = <0.001) (761.69 ± 114.01 vs. 684.16 ± 88.86) and MDA was significantly lower (p = <0.001) in TH group (1.73 ± 0.66 vs. 5.2 ± 1.06). Risk of developing deficit was lower (p < 0.001) in TH group with relative risk of 0.49 and 95 % confidence interval: 0.29-0.68.

CONCLUSION:

TH reduces oxidative stress and improves neurological outcome in perinatal asphyxia.

TRIAL REGISTRATION NUMBER:

CTRI/2011/12/002196.

PMID:
22907998
DOI:
10.1093/tropej/fms036
[Indexed for MEDLINE]

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