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Blood Purif. 2012;34(1):34-9. doi: 10.1159/000339816. Epub 2012 Aug 17.

Experimental first-pass method for testing and comparing sorbent polymers used in the clearance of iodine contrast materials.

Author information

1
Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. goangheloiu@drmc.org

Abstract

BACKGROUND:

Sorbents have been shown to adsorb iodinated radiocontrast media.

OBJECTIVE:

In this study we describe a simple method to compare various sorbents in terms of capacity to adsorb radiocontrast media.

METHODS:

Iodixanol solution was injected into columns filled with three types of sorbent at filtration velocities of increasing magnitude. Two variables of interest - contrast removal rate and matched iodine retention (MIR) - were calculated to measure the adsorption efficiency and the mass of contrast iodine adsorbed versus sorbent used, respectively.

RESULTS:

The highest contrast removal and MIR for Porapak Q, CST 401 and Amberlite XAD4 were 41, 38 and 16% (p = 0.22 and 0.0005 for comparisons between Porapak Q-CST 401 and CST 401-Amberlite XAD4) and 0.060, 0.055 and 0.024, respectively (p = 0.18 and 0.0008). Extrapolation to a clinical scenario may suggest that removal of 8 ml iodixanol could be achieved by masses of sorbents of 43, 47 and 107 g, respectively.

CONCLUSION:

In this study we set a benchmark for comparing the radiocontrast-adsorbing efficiency of polymer sorbents during first-pass experiments, using a readily available methodology.

PMID:
22907199
DOI:
10.1159/000339816
[Indexed for MEDLINE]

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