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Dermatology. 2012;225(1):75-80. doi: 10.1159/000341530. Epub 2012 Aug 17.

Phase-contrast microtomography with synchrotron radiation technology: a new noninvasive technique to analyze the three-dimensional structure of dermal tissues.

Author information

1
Shanghai Burn Institute, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, PR China.

Abstract

BACKGROUND:

Since the three-dimensional (3-D) structure of dermal tissue has an important role in regulating cell behavior and directing the wound healing process, the characteristic of the 3-D structure of dermal tissue needs to be clarified.

OBJECTIVE:

To explore the different 3-D structures between normal and scar dermal tissues.

MATERIAL AND METHODS:

Phase-contrast microtomography with synchrotron radiation technology was applied to detect the 3-D structure of dermal tissues.

RESULTS:

The normal dermal tissue consists of elliptical structures formed by fiber bundles interwoven in a helical manner. A regular louver-like structure was observed on the fibers. In scar tissue, the fiber bundles were arrayed in parallel, the louver-like structures were disordered.

CONCLUSION:

The study demonstrates the mesoscopic difference between normal dermal tissue and scar tissue, suggests that the high level of interweaving capability of collagen is compromised/lost when dermal tissue is injured, and provides a basis for future studies.

PMID:
22907159
DOI:
10.1159/000341530
[Indexed for MEDLINE]

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