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Annu Rev Cell Dev Biol. 2012;28:627-53. doi: 10.1146/annurev-cellbio-092910-154208. Epub 2012 Aug 16.

Planar cell polarity and the developmental control of cell behavior in vertebrate embryos.

Author information

1
Howard Hughes Medical Institute, Section of Molecular, Cell and Developmental Biology, University of Texas, Austin, Texas 78712, USA. wallingford@mail.utexas.edu

Abstract

Planar cell polarity (PCP), the orientation and alignment of cells within a sheet, is a ubiquitous cellular property that is commonly governed by the conserved set of proteins encoded by so-called PCP genes. The PCP proteins coordinate developmental signaling cues with individual cell behaviors in a wildly diverse array of tissues. Consequently, disruptions of PCP protein functions are linked to defects in axis elongation, inner ear patterning, neural tube closure, directed ciliary beating, and left/right patterning, to name only a few. This review attempts to synthesize what is known about PCP and the PCP proteins in vertebrate animals, with a particular focus on the mechanisms by which individual cells respond to PCP cues in order to execute specific cellular behaviors.

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