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Malar J. 2012 Aug 20;11:285. doi: 10.1186/1475-2875-11-285.

The extravascular compartment of the bone marrow: a niche for Plasmodium falciparum gametocyte maturation?

Author information

1
Laboratoire de parasitologie-mycologie, Assistance publique hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, 47 Boulevard de l'Hôpital, 75651 Paris Cedex 13, France.

Abstract

BACKGROUND:

Plasmodium falciparum immature gametocytes accumulate in the bone marrow, but their exact location in this tissue remains unclear.

METHODS:

The stage and deposition pattern of gametocytes was analysed on histological sections of a bone marrow sample collected in a patient with subacute P. falciparum malaria.

RESULTS:

A majority (89%) of immature stages II to IV gametocytes and a minority (29%) of mature stage V gametocytes were observed in extravascular spaces.

DISCUSSION AND CONCLUSION:

These observations represent a valuable step towards understanding sequestration patterns of P. falciparum gametocytes and may ultimately lead to novel transmission-blocking interventions.

PMID:
22905863
PMCID:
PMC3472181
DOI:
10.1186/1475-2875-11-285
[Indexed for MEDLINE]
Free PMC Article

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