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Am J Clin Pathol. 2012 Aug;138(2):230-5. doi: 10.1309/AJCPDHQFNYJZ01YG.

High expression of FoxP1 is associated with improved survival in patients with non-small cell lung cancer.

Author information

1
Department of Respiratory Medicine, Affiliated Hospital of Nantong University, Jiangsu, China.

Abstract

FoxP1 has been reported to be expressed in several types of human malignant tumors, and has been associated with metastasis and patient prognosis. Quantitative real-time polymerase chain reaction (PCR) and immunohistochemical analysis with tissue microarray were used to characterize the expression of FoxP1 in non-small cell lung cancer (NSCLC). It was revealed that the expression of FoxP1 messenger RNA (mRNA) and protein was significantly higher in NSCLC tissue than in corresponding peritumoral tissue (P = .013 and P < .001, respectively). The expression of FoxP1 protein in NSCLC was related to gender, histologic type, and 5-year survival rate (all P < .05). Finally, we evaluated the prognostic significance of the expression of FoxP1 in a group of patients. Kaplan-Meier survival and Cox regression analyses showed that low expression of FoxP1 (P < .001) and later stage grouping by TNM (P = .022) were independent factors predicting poor prognosis for NSCLC.

PMID:
22904134
DOI:
10.1309/AJCPDHQFNYJZ01YG
[Indexed for MEDLINE]

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