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Cell Mol Immunol. 2012 Sep;9(5):386-9. doi: 10.1038/cmi.2012.31. Epub 2012 Aug 20.

The role of the T follicular helper cells in allergic disease.

Author information

1
Department of Microbiology and Immunology Programme, National University of Singapore, Singapore. mickdm@nus.edu.sg

Abstract

T follicular helper (Tfh) cells were discovered just over a decade ago as germinal centre T cells that help B cells make antibodies. Included in this role is affinity maturation and isotype switching. It is here that their functions become less clear. Tfh cells principally produce IL-21 which inhibits class switching to IgE. Recent studies have questioned whether the germinal centre is the main site of IgE class switching or IgE affinity maturation. In this review, I will examine the evidence that these cells are responsible for regulating IgE class switching and the relationship between Tfh cells and T helper 2 (Th2) effector cells.

PMID:
22903050
PMCID:
PMC4002336
DOI:
10.1038/cmi.2012.31
[Indexed for MEDLINE]
Free PMC Article

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