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Cell Host Microbe. 2012 Aug 16;12(2):129-31. doi: 10.1016/j.chom.2012.07.006.

Linear ubiquitination of NEMO brakes the antiviral response.

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1
Wuhan Institute of Virology, State Key Laboratory of Virology, Chinese Academy of Sciences, China. wangyy@wh.iov.cn

Abstract

NEMO is a key component of antiviral signaling. Belgnaoui et al. (2012) discover that linear ubiquitination of NEMO at a late phase of virus infection switches NEMO from a positive to a negative regulator of RIG-I-mediated interferon (IFN) induction by disrupting the VISA/MAVS-TRAF3 complex and thus terminating the antiviral response.

PMID:
22901534
DOI:
10.1016/j.chom.2012.07.006
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