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Bioorg Med Chem Lett. 2012 Sep 15;22(18):5979-83. doi: 10.1016/j.bmcl.2012.07.035. Epub 2012 Aug 2.

Synthesis and biological activity of pyridopyridazin-6-one p38α MAP kinase inhibitors. Part 2.

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1
Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA. robert_tynebor@merck.com

Abstract

This manuscript concludes the Structure Activity Relationship (SAR) on the pyridazinone scaffold and identifies a compound with subnanomolar p38α activity and 24h coverage in the rat arthritis efficacy model.

PMID:
22901390
DOI:
10.1016/j.bmcl.2012.07.035
[Indexed for MEDLINE]
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