Format

Send to

Choose Destination
J Agric Food Chem. 2012 Sep 12;60(36):9130-6. doi: 10.1021/jf303440j. Epub 2012 Sep 4.

Acute effects of chlorogenic acid on nitric oxide status, endothelial function, and blood pressure in healthy volunteers: a randomized trial.

Author information

1
School of Medicine and Pharmacology, University of Western Australia, Australia.

Abstract

There is mounting evidence that specific dietary polyphenols can enhance vascular health by augmenting nitric oxide. Our aim was to investigate the acute effects of chlorogenic acid, an important dietary phenolic acid present in coffee (400 mg, equivalent to 2 cups of coffee), on nitric oxide status, endothelial function, and blood pressure. Healthy men and women (n = 23) were recruited to a randomized, double-blind, placebo-controlled, crossover trial. Chlorogenic acid resulted in significantly higher plasma concentrations of chlorogenic acid (P < 0.001). Relative to control, the mean post-treatment systolic blood pressure (-2.41 mmHg, 95% CI: -0.03, -4.78; P = 0.05) and diastolic blood pressure (-1.53 mmHg, 95% CI: -0.05, -3.01; P = 0.04) were significantly lower with chlorogenic acid. Markers of nitric oxide status (P > 0.10) and the measure of endothelial function (P = 0.60) were not significantly influenced. Chlorogenic acid can lower blood pressure acutely, an effect that, if sustained, would benefit cardiovascular health.

PMID:
22900702
DOI:
10.1021/jf303440j
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for American Chemical Society Icon for University of Western Australia Profiles and Research Repository
Loading ...
Support Center