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Biomarkers. 2012 Nov;17(7):648-54. doi: 10.3109/1354750X.2012.713004. Epub 2012 Aug 20.

Circulating and exhaled vascular endothelial growth factor in asthmatic pregnancy.

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1
Department of Pulmonology, Semmelweis University, Budapest, Hungary.

Abstract

CONTEXT:

Vascular endothelial growth factor (VEGF) plays a role in asthma and pathological pregnancies.

OBJECTIVE:

This is the first study assessing plasma and exhaled breath condensate VEGF levels in asthmatic pregnancy.

MATERIAL AND METHODS:

Thirty-one asthmatic pregnant, 29 asthmatic nonpregnant, 28 healthy pregnant and 22 healthy nonpregnant women were enrolled. Plasma was collected in all subjects, EBC in 57 volunteers for VEGF measurements.

RESULTS:

Plasma VEGF decreased in both pregnant groups (p < 0.01), without any differences between the asthmatic and the respective nonasthmatic groups (p > 0.05). VEGF was undetectable in EBC.

CONCLUSION:

Concomitant asthma does not affect plasma VEGF during pregnancy.

PMID:
22900522
DOI:
10.3109/1354750X.2012.713004
[Indexed for MEDLINE]
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