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PLoS One. 2012;7(8):e43061. doi: 10.1371/journal.pone.0043061. Epub 2012 Aug 10.

MRI correlates of disability in African-Americans with multiple sclerosis.

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1
Department of Neurology, Langone Medical Center, New York, New York, United States of America.

Erratum in

  • PLoS One. 2013;8(6). doi: 10.1371/annotation/25df480c-60b5-43a3-b03c-4e97d6ee399c.

Abstract

OBJECTIVES:

Multiple sclerosis (MS) in African-Americans (AAs) is characterized by more rapid disease progression and poorer response to treatment than in Caucasian-Americans (CAs). MRI provides useful and non-invasive tools to investigate the pathological substrate of clinical progression. The aim of our study was to compare MRI measures of brain damage between AAs and CAs with MS.

METHODS:

Retrospective analysis of 97 AAs and 97 CAs with MS matched for age, gender, disease duration and age at MRI examination.

RESULTS:

AA patients had significantly greater T2- (pā€Š=ā€Š0.001) and T1-weighted (pā€Š=ā€Š0.0003) lesion volumes compared to CA patients. In contrast, measurements of global and regional brain volume did not significantly differ between the two ethnic groups (p>0.1).

CONCLUSIONS:

By studying a quite large sample of well demographically and clinically matched CA and AA patients with a homogeneous MRI protocol we showed that higher lesion accumulation, rather than pronounced brain volume decrease might explain the early progress to ambulatory assistance of AAs with MS.

PMID:
22900088
PMCID:
PMC3416750
DOI:
10.1371/journal.pone.0043061
[Indexed for MEDLINE]
Free PMC Article
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