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Eye (Lond). 2012 Oct;26(10):1357-62. doi: 10.1038/eye.2012.165. Epub 2012 Aug 17.

Drusen prevalence and pigmentary changes in Caucasians aged 18-54 years.

Author information

1
Centre for Vision & Vascular Science, Queen's University of Belfast, Royal Victoria Hospital, Belfast, Antrim BT12 6BA, UK. g.silvestri@qub.ac.uk

Abstract

AIMS AND PURPOSE:

The aim of this study was to describe the prevalence and characteristics of drusen and pigmentary changes in a middle-aged population.

METHODS:

Retinal images from 500 individuals aged 18-54 years were included. The source of participants was two UK optometry practices. Retinal images were graded using the Wisconsin Age-Related Maculopathy Grading System. However, owing to the relatively young age of the population studied, a new category of drusen of smaller size (<31.5 μm) was introduced.

RESULTS:

Drusen were identified within the central macular grid in 91.48% of all gradable eyes and in 444 subjects. Drusen sized <31.5 μm were present in 89.7% of eyes, drusen sized >31.5 μm and <63 μm were present in 45.9% of all eyes and drusen >63 μm and <125 μm were present in only 1.7% of eyes. No eye had drusen larger or equal to 125 μm. Very few eyes (1.2%) showed pigmentary changes within the grid. Drusen load increased with increasing age, P <0.001.

CONCLUSIONS:

The frequency of drusen in a younger Caucasian population aged 18-54 years is high, with 91.48% of all gradable eyes having drusen. The most frequent drusen subtype was hard distinct drusen <31.5 μm. No druse greater or equal in size to 125 μm was seen. Pigmentary changes are rare.

PMID:
22899005
PMCID:
PMC3470061
DOI:
10.1038/eye.2012.165
[Indexed for MEDLINE]
Free PMC Article
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