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Nat Prod Rep. 2012 Nov;29(11):1277-87. doi: 10.1039/c2np20064c.

Bioactive natural products from Lysobacter.

Author information

1
Department of Chemistry, University of Nebraska-Lincoln, NE 68588, USA.

Abstract

The gliding Gram-negative Lysobacter bacteria are emerging as a promising source of new bioactive natural products. These ubiquitous freshwater and soil microorganisms are fast growing, simple to use and maintain, and genetically amenable for biosynthetic engineering. This Highlight reviews a group of biologically active and structurally distinct natural products from the genus Lysobacter, with a focus on their biosyntheses. Although Lysobacter sp. are known as prolific producers of bioactive natural products, detailed molecular mechanistic studies of their enzymatic assembly have been surprisingly scarce. We hope to provide a snapshot of the important work done on the lysobacterial natural products and to provide useful information for future biosynthetic engineering of novel antibiotics in Lysobacter.

PMID:
22898908
PMCID:
PMC3468324
DOI:
10.1039/c2np20064c
[Indexed for MEDLINE]
Free PMC Article

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