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Dev Cell. 2012 Aug 14;23(2):227-32. doi: 10.1016/j.devcel.2012.07.011.

Structural architecture and functional evolution of Wnts.

Author information

1
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA. jfbazan@gmail.com

Abstract

The crystal structure of a Wnt morphogen bound to its Frizzled receptor ectodomain provides insights into the evolutionary provenance of this complex fold and offers an explanation for why Wnts utilize both lipid- and protein-mediated contacts to engage Frizzleds.

PMID:
22898770
PMCID:
PMC3458506
DOI:
10.1016/j.devcel.2012.07.011
[Indexed for MEDLINE]
Free PMC Article

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