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Cancer Cell. 2012 Aug 14;22(2):235-49. doi: 10.1016/j.ccr.2012.06.013.

Small GTPase R-Ras regulates integrity and functionality of tumor blood vessels.

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1
Sanford-Burnham Medical Research Institute at Lake Nona, Orlando, FL 32827, USA.

Abstract

We show that R-Ras, a small GTPase of the Ras family, is essential for the establishment of mature, functional blood vessels in tumors. The genetic disruption of R-Ras severely impaired the maturation processes of tumor vessels in mice. Conversely, the gain of function of R-Ras improved vessel structure and blood perfusion and blocked plasma leakage by enhanced endothelial barrier function and pericyte association with nascent blood vessels. Thus, R-Ras promotes normalization of the tumor vasculature. These findings identify R-Ras as a critical regulator of vessel integrity and function during tumor vascularization.

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PMID:
22897853
PMCID:
PMC3422514
DOI:
10.1016/j.ccr.2012.06.013
[Indexed for MEDLINE]
Free PMC Article

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