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Int J Neurosci. 2012 Dec;122(12):742-7. doi: 10.3109/00207454.2012.721411. Epub 2012 Oct 11.

Administration of donepezil does not rescue galanin-induced spatial learning deficits.

Author information

1
Behavioral Neuroscience Laboratory, University of Nevada , Las Vegas, Las Vegas, Nevada 89154, USA. sabbaghj@unlv.nevada.edu

Abstract

The neuropeptide galanin inhibits the evoked release of several neurotransmitters including acetylcholine and modulates adenylate cyclase (AC) activity. Galanin has also been established to impair various forms of learning and memory in rodents. However, whether galanin produces learning deficits by inhibiting cholinergic activity or decreasing AC function has not been clearly established. The current study investigated if donepezil, an acetylcholinesterase inhibitor utilized in Alzheimer's disease, could rescue galanin-induced Morris water task deficits in rats. The results demonstrated that donepezil did not alter the previously established deficits induced by galanin. These findings suggest that galanin-mediated spatial learning deficits may be unrelated to its modulation of the cholinergic system.

PMID:
22897394
DOI:
10.3109/00207454.2012.721411
[Indexed for MEDLINE]

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