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Gynecol Obstet Invest. 1990;30(4):239-41.

Human recombinant interleukin-1 alpha increases elastase-like enzyme in human uterine cervical fibroblasts.

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Department of Biochemistry, Tokyo College of Pharmacy, Japan.


Production of the elastase-like enzyme, Suc-(Ala)3-p-nitroanilide hydrolase, was examined in human uterine cervical fibroblasts. The metallo-dependent enzyme is present in both media and cellular fractions. Human recombinant interleukin-1 alpha stimulated cells to produce and secrete this elastase-like enzyme. These results suggest that modulation of this enzyme activity by interleukin-1 may play a significant role in the ripening and dilation of the cervix, because elastin is a component of the uterine cervix and its peptides are known to be chemotactic for leukocytes.

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