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J Virol. 2012 Nov;86(21):11919-25. doi: 10.1128/JVI.01066-12. Epub 2012 Aug 15.

Reconstitution of the entire hepatitis C virus life cycle in nonhepatic cells.

Author information

1
INSERM, U748, Strasbourg, France.

Abstract

Hepatitis C virus (HCV) is a human hepatotropic virus, but the relevant host factors restricting HCV infection to hepatocytes are only partially understood. We demonstrate that exogenous expression of defined host factors reconstituted the entire HCV life cycle in human nonhepatic 293T cells. This study shows robust HCV entry, RNA replication, and production of infectious virus in human nonhepatic cells and highlights key host factors required for liver tropism of HCV.

PMID:
22896615
PMCID:
PMC3486316
DOI:
10.1128/JVI.01066-12
[Indexed for MEDLINE]
Free PMC Article

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