Send to

Choose Destination
Nat Rev Mol Cell Biol. 2012 Sep;13(9):591-600. doi: 10.1038/nrm3416. Epub 2012 Aug 16.

Transduction of mechanical and cytoskeletal cues by YAP and TAZ.

Author information

Viaams Instituut voor Biotechnologie Center for the Biology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.


The physical and mechanical properties of the cellular microenvironment regulate cell shape and can strongly influence cell fate. How mechanical cues are sensed and transduced to regulate gene expression has long remained elusive. Recently, cues from the extracellular matrix, cell adhesion sites, cell shape and the actomyosin cytoskeleton were found to converge on the regulation of the downstream effectors of the Hippo pathway YAP (Yes-associated protein) and TAZ (transcriptional co-activator with PDZ-binding motif) in vertebrates and Yorkie in flies. This convergence may explain how mechanical signals can direct normal and pathological cell behaviour.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center