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Nat Rev Mol Cell Biol. 2012 Sep;13(9):591-600. doi: 10.1038/nrm3416. Epub 2012 Aug 16.

Transduction of mechanical and cytoskeletal cues by YAP and TAZ.

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1
Viaams Instituut voor Biotechnologie Center for the Biology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.

Abstract

The physical and mechanical properties of the cellular microenvironment regulate cell shape and can strongly influence cell fate. How mechanical cues are sensed and transduced to regulate gene expression has long remained elusive. Recently, cues from the extracellular matrix, cell adhesion sites, cell shape and the actomyosin cytoskeleton were found to converge on the regulation of the downstream effectors of the Hippo pathway YAP (Yes-associated protein) and TAZ (transcriptional co-activator with PDZ-binding motif) in vertebrates and Yorkie in flies. This convergence may explain how mechanical signals can direct normal and pathological cell behaviour.

PMID:
22895435
DOI:
10.1038/nrm3416
[Indexed for MEDLINE]

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