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J Biomed Opt. 2012 Jul;17(7):076018. doi: 10.1117/1.JBO.17.7.076018.

Frequency domain multiplexing for speckle reduction in optical coherence tomography.

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Thorax Center, Erasmus MC, Rotterdam, The Netherlands.

Erratum in

  • J Biomed Opt. 2012 Sep 17(9):099801.


Quantitative analysis of optical coherence tomography data can be strongly hampered by speckle. Here, we introduce a new method to reduce speckle, which leverages from Fourier-domain configurations and operates on individual axial scans. By subdividing the digitized spectrum into a number of distinct narrower windows, each with a different center frequency, several independent speckle patterns result. These can be averaged to yield a lower-resolution image with strongly reduced speckle. The full resolution image remains available for human interpretation; the low resolution version can be used for parametric imaging or quantitative analysis. We demonstrate this technique using intravascular optical frequency domain imaging data acquired in vivo.

[Indexed for MEDLINE]

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