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Eur J Pharmacol. 1979 Oct 26;59(1-2):121-3.

A possibe alpha-adrenergic mechanism for drug (CRL 40028)-induced hyperactivity.

Abstract

CRL 40028 (benzhydryl sulfinyl acetohydroxamic acid)-induced stimulation in mice, measured as an increase in locomotor activity was studied following an intraperitoneal injection of drugs known to block alpha-adrenergic receptors. Phenoxybenzamine (20 mg/kg), prazosin (0.5-1 mg/kg) and yohimbine (2 mg/kg) prevented the development of CRL 40028-induced hyperactivity. These results suggest that stimulation of an alpha-adrenergic postsynaptic receptor is of importance for the stimulant effect of CRL 40028.

PMID:
228945
[Indexed for MEDLINE]

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