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J Biomed Opt. 2012 Jul;17(7):071311. doi: 10.1117/1.JBO.17.7.071311.

Diffuse optical imaging using spatially and temporally modulated light.

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1
University of California, Irvine, Laser Microbeam and Medical Program (LAMMP), Beckman Laser Institute and Medical Clinic, Irvine, California, USA.

Abstract

The authors describe the development of diffuse optical imaging (DOI) technologies, specifically the use of spatial and temporal modulation to control near infrared light propagation in thick tissues. We present theory and methods of DOI focusing on model-based techniques for quantitative, in vivo measurements of endogenous tissue absorption and scattering properties. We specifically emphasize the common conceptual framework of the scalar photon density wave for both temporal and spatial frequency-domain approaches. After presenting the history, theoretical foundation, and instrumentation related to these methods, we provide a brief review of clinical and preclinical applications from our research as well as our outlook on the future of DOI technology.

PMID:
22894472
PMCID:
PMC3607494
DOI:
10.1117/1.JBO.17.7.071311
[Indexed for MEDLINE]
Free PMC Article
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