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Kidney Int. 2012 Sep;82(5):509-11. doi: 10.1038/ki.2012.155.

Role changes of β-catenin in kidney injury and repair.

Abstract

Using conditional knockout models, Zhou et al. firmly establish a renoprotective role of β-catenin in acute kidney injury. Although β-catenin is protective at the injury phase, whether it helps kidney repair remains in question. In a renal cell scratch model, β-catenin suppresses wound healing. Moreover, continuous activation of β-catenin may lead to renal fibrosis. Further investigation should elucidate the distinct roles played by β-catenin and related signaling in kidney injury, repair, and fibrosis.

PMID:
22892856
DOI:
10.1038/ki.2012.155
[Indexed for MEDLINE]
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