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Brain Res. 1990 Nov 19;533(2):348-52.

MK-801 antagonizes methamphetamine-induced decreases in hippocampal and striatal corticosteroid receptors.

Author information

1
Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH 44106.

Abstract

Administration of methamphetamine (15 mg/kg) to adrenalectomized rats significantly decreased hippocampal type I and II corticosteroid receptors as well as type II receptors in the striatum. Type II receptors in the frontal cortex and hypothalamus were unaffected by methamphetamine administration. Pretreatment with MK-801, a non-competitive antagonist of N-methyl-D-aspartate receptors, antagonized the methamphetamine-induced decrease in hippocampal and striatal corticosteroid receptors. These results are in agreement with previous studies demonstrating that some of the neurobiological effects of methamphetamine may be mediated via a mechanism involving excitatory amino acids.

PMID:
2289150
DOI:
10.1016/0006-8993(90)91362-k
[Indexed for MEDLINE]

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