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J Hematol Oncol. 2012 Aug 13;5:50.

Acute graft versus host disease after orthotopic liver transplantation.

Author information

1
University of Zagreb School of Medicine, University Hospital Merkur, Zagreb, Croatia.

Abstract

Graft versus host disease (GVHD) is an uncommon complication after orthotopic liver transplantation (OLT) with an incidence of 0.1-2%, but an 80-100% mortality rate. Patients can present with skin rashes, diarrhea, and bone marrow aplasia between two to eight weeks after OLT. Diagnosis of GVHD is made based on clinical and histologic evidence, supported by chimerism studies showing donor HLA alleles in the recipient bone marrow or blood. Several therapeutic approaches have been used for the management of GVHD after OLT including increased immunosuppression, decreased immunosuppression, and cellular therapies. However, success rates have been low, and new approaches are needed.

PMID:
22889203
PMCID:
PMC3445845
DOI:
10.1186/1756-8722-5-50
[Indexed for MEDLINE]
Free PMC Article

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