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Nat Prod Res. 2013;27(10):916-9. doi: 10.1080/14786419.2012.668693. Epub 2012 Mar 9.

Chemical constituents, anti-inflammatory and antioxidant activities of bark extracts from Prunus tucumanensis Lillo.

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1
Facultad de Bioquímica Química y Farmacia, INQUINOA-CONICET, Instituto de Química Orgánica, Universidad Nacional de Tucumán, S. M. de Tucumán T4000INI, Argentina.

Abstract

The anti-inflammatory, antioxidant, antimicrobial and cytotoxic activities of the hexane (HE), chloroform (CE) and methanol (ME) extracts obtained from the bark of Prunus tucumanensis Lillo were investigated. Both ME and CE extracts displayed a significant in vitro anti-inflammatory activity similar to dexamethasone and to a commercial formulation (Pygeum) used for the treatment of benign prostatic hyperplasia (BPH). ME exhibited powerful antioxidant (67.6% relative to BHT) and free radical scavenging (RC50 = 5 ppm) activities, antimicrobial activities against Staphylococcus aureus and Mycobacterium smegmatis and did not show any cytotoxic effect on human-derived macrophage cells. Chemical analyses showed that (2 R,3 R)-3,5,7,3',5'-pentahydroxyflavan, β-sitosterol and β-sitosterol-3-O-β-D-glucopyranoside (daucosterol) are relevant components of ME.

PMID:
22889184
DOI:
10.1080/14786419.2012.668693
[Indexed for MEDLINE]
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