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Mult Scler Int. 2012;2012:530305. doi: 10.1155/2012/530305. Epub 2012 Jul 25.

Retinal damage in multiple sclerosis disease subtypes measured by high-resolution optical coherence tomography.

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1
NeuroCure Clinical Research Center and Experimental and Clinical Research Center, Charité University Medicine Berlin/Max Delbrück Center for Molecular Medicine, 10117 Berlin, Germany.

Abstract

BACKGROUND:

Optical coherence tomography (OCT) has facilitated characterisation of retinal alterations in MS patients. Only scarce and in part conflicting data exists on different MS subtypes.

OBJECTIVE:

To analyse patterns of retinal changes in different subtypes of MS with latest spectral-domain technology.

METHODS:

In a three-centre cross-sectional study 414 MS patients and 94 healthy controls underwent spectral-domain OCT examination.

RESULTS:

Eyes of MS patients without a previous optic neuritis showed a significant reduction of both retinal nerve fibre layer (RNFL) thickness and total macular volume (TMV) compared to healthy controls independent of the MS subtype (P < 0.001 for all subtypes). RNFL thickness was lower in secondary progressive MS (SPMS) eyes compared to relapsing-remitting MS (RRMS) eyes (P = 0.007), and TMV was reduced in SPMS and primary progressive MS (PPMS) eyes compared to RRMS eyes (SPMS: P = 0.039, PPMS: P = 0.005). Independent of the subtype a more pronounced RNFL thinning and TMV reduction were found in eyes with a previous optic neuritis compared to unaffected eyes.

CONCLUSION:

Analysis of this large-scale cross-sectional dataset of MS patients studied with spectral-domain OCT confirmed and allows to generalize previous findings. Furthermore it carves out distinct patterns in different MS subtypes.

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