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Mol Biol Int. 2012;2012:868597. doi: 10.1155/2012/868597. Epub 2012 Jul 19.

The Role of TNPO3 in HIV-1 Replication.

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1
Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1301 Morris Park, Price Center 501, New York, NY 10461, USA.

Abstract

TNPO3, transportin-SR2 or Tnp3, a member of the karyopherin β superfamily of proteins, is important for the ability of human immunodeficiency virus (HIV-1) to achieve productive infection, as TNPO3 depletion in human cells leads to a dramatic reduction of infection. Here we describe and discuss recent findings suggesting that TNPO3 assists HIV-1 replication in the nucleus and in fact that TNPO3 may assist PIC maturation in the nucleus. In addition, the viral determinant for the requirement of TNPO3 in HIV-1 infection is discussed. This paper summarizes the most significant recent discoveries about this important host factor and its role in HIV-1 replication.

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