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Transl Stroke Res. 2012 Jun;3(2):263-5. doi: 10.1007/s12975-012-0152-2.

Brain water content. A misunderstood measurement?

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Departments of Neurosurgery, University of Michigan, Ann Arbor, Michigan.


Brain edema is a major contributor to poor outcome following ischemic and hemorrhagic stroke. In animal models, edema has historically been quantified as a change in % brain water content (water content/wet weight). As described in this communication, this number can be misleading, as 'small' changes in % brain water content actually reflect much bigger changes in brain swelling. Using either water content, expressed as g/g dry weight, or a measure of brain swelling, better reflect the impact of edema after stroke and brain injury.

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