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Front Immunol. 2012 Aug 6;3:228. doi: 10.3389/fimmu.2012.00228. eCollection 2012.

Akt and mTOR in B Cell Activation and Differentiation.

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Department of Molecular Biology and Biochemistry, Institute for Immunology, University of California Irvine Irvine, CA, USA.


Activation of phosphoinositide 3-kinase (PI3K) is required for B cell proliferation and survival. PI3K signaling also controls key aspects of B cell differentiation. Upon engagement of the B cell receptor (BCR), PI3K activation promotes Ca(2+) mobilization and activation of NFκB-dependent transcription, events which are essential for B cell proliferation. PI3K also initiates a distinct signaling pathway involving the Akt and mTOR serine/threonine kinases. It has been generally assumed that activation of Akt and mTOR downstream of PI3K is essential for B cell function. However, Akt and mTOR have complex roles in B cell fate decisions and suppression of this pathway can enhance certain B cell responses while repressing others. In this review we will discuss genetic and pharmacological studies of Akt and mTOR function in normal B cells, and in malignancies of B cell origin.


Akt; B cells; PI3K; antibody; differentiation; kinase; mTOR; proliferation

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