Format

Send to

Choose Destination
Front Immunol. 2012 Aug 6;3:228. doi: 10.3389/fimmu.2012.00228. eCollection 2012.

Akt and mTOR in B Cell Activation and Differentiation.

Author information

1
Department of Molecular Biology and Biochemistry, Institute for Immunology, University of California Irvine Irvine, CA, USA.

Abstract

Activation of phosphoinositide 3-kinase (PI3K) is required for B cell proliferation and survival. PI3K signaling also controls key aspects of B cell differentiation. Upon engagement of the B cell receptor (BCR), PI3K activation promotes Ca(2+) mobilization and activation of NFκB-dependent transcription, events which are essential for B cell proliferation. PI3K also initiates a distinct signaling pathway involving the Akt and mTOR serine/threonine kinases. It has been generally assumed that activation of Akt and mTOR downstream of PI3K is essential for B cell function. However, Akt and mTOR have complex roles in B cell fate decisions and suppression of this pathway can enhance certain B cell responses while repressing others. In this review we will discuss genetic and pharmacological studies of Akt and mTOR function in normal B cells, and in malignancies of B cell origin.

KEYWORDS:

Akt; B cells; PI3K; antibody; differentiation; kinase; mTOR; proliferation

Supplemental Content

Full text links

Icon for Frontiers Media SA Icon for PubMed Central
Loading ...
Support Center