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Angew Chem Int Ed Engl. 2012 Sep 3;51(36):9047-51. doi: 10.1002/anie.201204198. Epub 2012 Aug 6.

Phosphatase-triggered fusogenic liposomes for cytoplasmic delivery of cell-impermeable compounds.

Author information

1
University of California, Berkeley, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143-0912, USA.

Abstract

License to fuse! A phosphorylated fusion peptide can mediate membrane fusion when the phosphates (green triangles, see scheme) are removed by phosphatases (blue spheres), delivering the contents of the liposome into the cytosol. This phosphatase-triggered approach may be useful to create target-specific lipid nanocarriers.

PMID:
22887437
PMCID:
PMC3470804
DOI:
10.1002/anie.201204198
[Indexed for MEDLINE]
Free PMC Article

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