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Biotechnol Appl Biochem. 1990 Oct;12(5):473-7.

Regulation of the epidermal growth factor receptor by growth-modulating agents.

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Ben May Institute, University of Chicago, Illinois 60637.


The epidermal growth factor (EGF) receptor, a tyrosine kinase which mediates the mitogenic and tumorigenic action of EGF on epithelial cells and fibroblasts, is a target for the regulatory action of other growth-modulating agents. We have identified at least three mechanisms by which heterologous agents such as tumor promoters regulate the EGF receptor: modulation of receptor binding or kinase activity through phosphorylation, down regulation of the receptor through internalization, and enhanced receptor synthesis through transcriptional activation. Both calcium- and sodium-dependent signaling pathways play a role in one or more of these processes.

[Indexed for MEDLINE]

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