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Med Res Rev. 2012 Sep;32(5):999-1025. doi: 10.1002/med.20231. Epub 2010 Nov 9.

Multifunctional roles of gelsolin in health and diseases.

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Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.


Gelsolin, a Ca(2+) -regulated actin filament severing, capping, and nucleating protein, is an ubiquitous, multifunctional regulator of cell structure and metabolism. More recent data show that gelsolin can act as a transcriptional cofactor in signal transduction and its own expression and function can be influenced by epigenetic changes. Here, we review the functions of the plasma and cytoplasmic forms of gelsolin, and their manifold impacts on cancer, apoptosis, infection and inflammation, cardiac injury, pulmonary diseases, and aging. An improved understanding of the functions and regulatory mechanisms of gelsolin may lead to new considerations of this protein as a potential biomarker and/or therapeutic target.

[Indexed for MEDLINE]

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