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Curr Top Microbiol Immunol. 2013;363:21-41. doi: 10.1007/82_2012_247.

Studying Salmonellae and Yersiniae host-pathogen interactions using integrated 'omics and modeling.

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1
Biological Separations and Mass Spectroscopy Group, Pacific Northwest National Laboratory, PO Box 999, MSIN: K8-98, Richland, WA, 99352, USA.

Abstract

Salmonella and Yersinia are two distantly related genera containing species with wide host-range specificity and pathogenic capacity. The metabolic complexity of these organisms facilitates robust lifestyles both outside of and within animal hosts. Using a pathogen-centric systems biology approach, we are combining a multi-omics (transcriptomics, proteomics, metabolomics) strategy to define properties of these pathogens under a variety of conditions including those that mimic the environments encountered during pathogenesis. These high-dimensional omics datasets are being integrated in selected ways to improve genome annotations, discover novel virulence-related factors, and model growth under infectious states. We will review the evolving technological approaches toward understanding complex microbial life through multi-omic measurements and integration, while highlighting some of our most recent successes in this area.

PMID:
22886542
DOI:
10.1007/82_2012_247
[Indexed for MEDLINE]
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