Growth hormone receptors in hypothalamic and extra-hypothalamic tissues

R A Fraser; D Attardo; S Harvey

doi:10.1677/jme.0.0050231

Growth hormone receptors in hypothalamic and extra-hypothalamic tissues

J Mol Endocrinol. 1990 Dec;5(3):231-8. doi: 10.1677/jme.0.0050231.

Authors

R A Fraser¹, D Attardo, S Harvey

Affiliation

¹ Department of Physiology, University of Alberta, Edmonton, Canada.

PMID: 2288635
DOI: 10.1677/jme.0.0050231

Abstract

Central GH receptors (GHR) have been identified in hypothalamic and extra-hypothalamic tissues of rabbit and chicken brains. Plasma membranes of the rabbit brain demonstrated specific saturable high-affinity, low-capacity binding sites for 125I-labelled GH. RNA extracted from hypothalamic and extra-hypothalamic tissues of rabbit and chicken brains contained mRNA that hybridized with a cDNA probe for the rabbit liver GHR. This transcript was of a similar size to the major GHR mRNA moiety in rabbit liver. The expression of these moieties was age related, and higher in adult than in neonatal animals.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Age Factors
Animals
Binding Sites / physiology
Brain Chemistry*
Chickens
DNA Probes / chemical synthesis
Hypothalamus / chemistry*
Liver
RNA Probes / chemical synthesis
Rabbits
Receptors, Somatotropin / analysis
Receptors, Somatotropin / physiology*

Substances

DNA Probes
RNA Probes
Receptors, Somatotropin